Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2

Abstract

This research work aims to evaluate the evaluation of guava leaf powder on blood glucose levels in rats (Sprague-Dawley) induced by diabetes mellitus type 2 (DM2) with the drug streptozotocin (STZ). This research has a quantitative approach, experimental design, explanatory and longitudinal cut. The sample consisted of 40 male rats of the Sprague-Dawley strain of 5 weeks, distributed in 3 treatment groups: non-diabetic control group, experimental group 2 and experimental group 3 respectively. For the induction process of diabetes type 2, the rats received an amount of 10% fructose for two weeks, then the drug streptozotocin (STZ) was administered intraperitoneally (50mg / kg). The experimental groups were fed by an orogastric tube, with a dose of 500mg / Kg and 1000mg / Kg of guava leaf powder, for the experimental groups comprising group 2 and group 3, respectively, for a period of 3 weeks . At the end of the treatment, the experimental groups showed a significant decrease in glycemia and a decrease in body weight. This study concludes that the dose of 1000mg / Kg of the guava leaf powder shows a greater decrease in glycemia, after consumption.